Artículos
Publicado 2024-10-31
Palabras clave
- células supresoras de origen mieloide,
- MDSC,
- enfermedad periodontal,
- afecciones inflamatorias
Resumen
La enfermedad periodontal (EP) es una condición inflamatoria altamente prevalente que ha sido asociada a diferentes enfermedades. Diversos factores inmunológicos están involucrados en dicha asociación. Las células supresoras de origen mieloide (MDSC) son células mieloides inmaduras que suprimen la respuesta de células T, participan en la remodelación ósea y han sido involucradas en diferentes enfermedades. El objetivo del presente trabajo es revisar y discutir aspectos biológicos de las MDSC en el contexto de la EP y otras afecciones inflamatorias. Las MDSC se han analizado en modelos murinos de EP en asociación con otras afecciones y en tejido periodontal humano. Se ha reportado una mayor acumulación de MDSC en presencia de EP en asociación con obesidad, artritis y cáncer, así como exacerbación de las características clínicas de la enfermedad y en algunos casos las MDSC presentaron participación potencial en osteoclastogenesis. Las MDSC podrían representar un mecanismo bidireccional conectando a la EP con otros padecimientos inflamatorios.
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Referencias
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Bizymi, N., Matthaiou, A. M., Mavroudi, I., Batsali, A., & Papadaki, H. A. (2024). Immunomodulatory actions of myeloid-derived suppressor cells in the context of innate immunity. Innate Immunity, 30(1), 2–10. https://doi.org/10.1177/17534259231215581
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Codella, R., Della Guardia, L., Terruzzi, I., Solini, A., Folli, F., Varoni, E. M., Carrassi, A., & Luzi, L. (2021). Physical activity as a proxy to ameliorate inflammation in patients with type 2 diabetes and periodontal disease at high cardiovascular risk. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD, 31(8),2199–2209.https://doi.org/10.1016/j.numecd.2021.04.022
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Li, Z., Xia, Q., He, Y., Li, L., & Yin, P. (2024). MDSCs in bone metastasis: Mechanisms and therapeutic potential. Cancer Letters, 592, 216906. https://doi.org/10.1016/j.canlet.2024.216906
Liu, J., Li, T., Zhang, S., Lu, E., Qiao, W., Chen, H., Liu, P., Tang, X., Cheng, T., & Chen, H. (2023). Proteomic and single-cell analysis shed new light on the anti-inflammatory role of interferonβ in chronic periodontitis. Frontiers in Pharmacology, 14, 1232539. https://doi.org/10.3389/fphar.2023.1232539
Pitones-Rubio, V., Chávez-Cortez, E. G., Hurtado-Camarena, A., González-Rascón, A., & Serafín-Higuera, N. (2020). Is periodontal disease a risk factor for severe COVID-19 illness? Medical Hypotheses, 144, 109969. https://doi.org/10.1016/j.mehy.2020.109969
Ren, Y., Bäcker, H., Müller, M., & Kienzle, A. (2023). The role of myeloid derived suppressor cells in musculoskeletal disorders. Frontiers in Immunology, 14, 1139683. https://doi.org/10.3389/fimmu.2023.1139683
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2018). The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of Alzheimer’s disease. Cellular and Molecular Life Sciences: CMLS, 75(17),3099–3120.https://doi.org/10.1007/s00018-018-2844-6
Valero-Monroy, O., Garcia-Cervantes, G., Marquez-Corrales, L. F., Leija-Montoya, A. G., Sandoval-Basilio, J., Martinez-Coronilla, G., Isiordia-Espinoza, M. A., & Serafin-Higuera, N. (2016). Myeloid derived suppressor cell: A new player in periodontal disease? Medical Hypotheses, 95, 35–38. https://doi.org/10.1016/j.mehy.2016.08.010
Wu, Q., Zhang, W., Lu, Y., Li, H., Yang, Y., Geng, F., Liu, J., Lin, L., Pan, Y., & Li, C. (2024). Association between periodontitis and inflammatory comorbidities: The common role of innate immune cells, underlying mechanisms and therapeutic targets. International Immunopharmacology, 128, 111558. https://doi.org/10.1016/j.intimp.2024.111558
Yang, K., Zhang, Z., Zhang, Q., Zhang, H., Liu, X., Jia, Z., Ying, Z., & Liu, W. (2024). Potential diagnostic markers and therapeutic targets for periodontitis and Alzheimer’s disease based on bioinformatics analysis. Journal of Periodontal Research, 59(2), 366–380. https://doi.org/10.1111/jre.13220
Zhou, N., Zou, F., Cheng, X., Huang, Y., Zou, H., Niu, Q., Qiu, Y., Shan, F., Luo, A., Teng, W., & Sun, J. (2021). Porphyromonas gingivalis induces periodontitis, causes immune imbalance, and promotes rheumatoid arthritis. Journal of Leukocyte Biology, 110(3), 461–473. https://doi.org/10.1002/JLB.3MA0121-045R
Bekić, M., & Tomić, S. (2023). Myeloid-derived suppressor cells in the therapy of autoimmune diseases. European Journal of Immunology, 53(12), e2250345. https://doi.org/10.1002/eji.202250345
Bizymi, N., Matthaiou, A. M., Mavroudi, I., Batsali, A., & Papadaki, H. A. (2024). Immunomodulatory actions of myeloid-derived suppressor cells in the context of innate immunity. Innate Immunity, 30(1), 2–10. https://doi.org/10.1177/17534259231215581
Budhwar, S., Verma, P., Verma, R., Rai, S., & Singh, K. (2018). The Yin and Yang of Myeloid Derived Suppressor Cells. Frontiers in Immunology, 9, 2776. https://doi.org/10.3389/fimmu.2018.02776
Cheng, R., Billet, S., Liu, C., Haldar, S., Choudhury, D., Tripathi, M., Hav, M., Merchant, A., Hu, T., Huang, H., Zhou, H., & Bhowmick, N. A. (2020). Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells. Oncogene, 39(7), 1543–1556.https://doi.org/10.1038/s41388-019-1084-z
Codella, R., Della Guardia, L., Terruzzi, I., Solini, A., Folli, F., Varoni, E. M., Carrassi, A., & Luzi, L. (2021). Physical activity as a proxy to ameliorate inflammation in patients with type 2 diabetes and periodontal disease at high cardiovascular risk. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD, 31(8),2199–2209.https://doi.org/10.1016/j.numecd.2021.04.022
Duan, A., Zhang, Y., & Yuan, G. (2023). Screening of feature genes related to immune and inflammatory responses in periodontitis. BMC Oral Health, 23(1), 234. https://doi.org/10.1186/s12903-023-02925-z
García-Arévalo, F., Leija-Montoya, A. G., González-Ramírez, J., Isiordia-Espinoza, M., Serafín-Higuera, I., Fuchen-Ramos, D. M., Vazquez-Jimenez, J. G., & Serafín-Higuera, N. (2024). Modulation of myeloid-derived suppressor cell functions by oral inflammatory diseases and important oral pathogens. Frontiers in Immunology, 15, 1349067. https://doi.org/10.3389/fimmu.2024.1349067
Hajishengallis, G., & Chavakis, T. (2021). Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nature Reviews. Immunology, 21(7), 426–440. https://doi.org/10.1038/s41577-020-00488-6
Hu, S., Li, S., Ning, W., Huang, X., Liu, X., Deng, Y., Franceschi, D., Ogbuehi, A. C., Lethaus, B., Savkovic, V., Li, H., Gaus, S., Zimmerer, R., Ziebolz, D., Schmalz, G., & Huang, S. (2022). Identifying crosstalk genetic biomarkers linking a neurodegenerative disease, Parkinson’s disease, and periodontitis using integrated bioinformatics analyses. Frontiers in Aging Neuroscience, 14, 1032401. https://doi.org/10.3389/fnagi.2022.1032401
Huang, J., Zhao, Y., Zhao, K., Yin, K., & Wang, S. (2023). Function of reactive oxygen species in myeloid-derived suppressor cells. Frontiers in Immunology, 14, 1226443. https://doi.org/10.3389/fimmu.2023.1226443
Kwack, K. H., Maglaras, V., Thiyagarajan, R., Zhang, L., & Kirkwood, K. L. (2021). Myeloid-derived suppressor cells in obesity-associated periodontal disease: A conceptual model. Periodontology 2000, 87(1), 268–275. https://doi.org/10.1111/prd.12384
Kwack, K. H., Zhang, L., Sohn, J., Maglaras, V., Thiyagarajan, R., & Kirkwood, K. L. (2022). Novel Preosteoclast Populations in Obesity-Associated Periodontal Disease. Journal of Dental Research, 101(3), 348–356. https://doi.org/10.1177/00220345211040729
Larvin, H., Kang, J., Aggarwal, V. R., Pavitt, S., & Wu, J. (2023). Periodontitis and risk of immune-mediated systemic conditions: A systematic review and meta-analysis. Community Dentistry and Oral Epidemiology, 51(5), 705–717. https://doi.org/10.1111/cdoe.12812
Leija-Montoya, A. G., González-Ramírez, J., Serafín-Higuera, I., Sandoval-Basilio, J., Isiordia-Espinoza, M., & Serafín-Higuera, N. (2023). Emerging avenues linking myeloid-derived suppressor cells to periodontal disease. En International Review of Cell and Molecular Biology. Academic Press. https://doi.org/10.1016/bs.ircmb.2022.12.001
Li, Z., Xia, Q., He, Y., Li, L., & Yin, P. (2024). MDSCs in bone metastasis: Mechanisms and therapeutic potential. Cancer Letters, 592, 216906. https://doi.org/10.1016/j.canlet.2024.216906
Liu, J., Li, T., Zhang, S., Lu, E., Qiao, W., Chen, H., Liu, P., Tang, X., Cheng, T., & Chen, H. (2023). Proteomic and single-cell analysis shed new light on the anti-inflammatory role of interferonβ in chronic periodontitis. Frontiers in Pharmacology, 14, 1232539. https://doi.org/10.3389/fphar.2023.1232539
Pitones-Rubio, V., Chávez-Cortez, E. G., Hurtado-Camarena, A., González-Rascón, A., & Serafín-Higuera, N. (2020). Is periodontal disease a risk factor for severe COVID-19 illness? Medical Hypotheses, 144, 109969. https://doi.org/10.1016/j.mehy.2020.109969
Ren, Y., Bäcker, H., Müller, M., & Kienzle, A. (2023). The role of myeloid derived suppressor cells in musculoskeletal disorders. Frontiers in Immunology, 14, 1139683. https://doi.org/10.3389/fimmu.2023.1139683
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2018). The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of Alzheimer’s disease. Cellular and Molecular Life Sciences: CMLS, 75(17),3099–3120.https://doi.org/10.1007/s00018-018-2844-6
Valero-Monroy, O., Garcia-Cervantes, G., Marquez-Corrales, L. F., Leija-Montoya, A. G., Sandoval-Basilio, J., Martinez-Coronilla, G., Isiordia-Espinoza, M. A., & Serafin-Higuera, N. (2016). Myeloid derived suppressor cell: A new player in periodontal disease? Medical Hypotheses, 95, 35–38. https://doi.org/10.1016/j.mehy.2016.08.010
Wu, Q., Zhang, W., Lu, Y., Li, H., Yang, Y., Geng, F., Liu, J., Lin, L., Pan, Y., & Li, C. (2024). Association between periodontitis and inflammatory comorbidities: The common role of innate immune cells, underlying mechanisms and therapeutic targets. International Immunopharmacology, 128, 111558. https://doi.org/10.1016/j.intimp.2024.111558
Yang, K., Zhang, Z., Zhang, Q., Zhang, H., Liu, X., Jia, Z., Ying, Z., & Liu, W. (2024). Potential diagnostic markers and therapeutic targets for periodontitis and Alzheimer’s disease based on bioinformatics analysis. Journal of Periodontal Research, 59(2), 366–380. https://doi.org/10.1111/jre.13220
Zhou, N., Zou, F., Cheng, X., Huang, Y., Zou, H., Niu, Q., Qiu, Y., Shan, F., Luo, A., Teng, W., & Sun, J. (2021). Porphyromonas gingivalis induces periodontitis, causes immune imbalance, and promotes rheumatoid arthritis. Journal of Leukocyte Biology, 110(3), 461–473. https://doi.org/10.1002/JLB.3MA0121-045R