Artículos
Expresión de BAX y Bcl-2 en folículos dentales: Estudio preliminar
Isis Mateos-Corral- Luis Fernando Jacinto-Alemán, Dr.
- Rogelio González-González, Dr.
- Anna González-Rascón, Dra.
- Fátima Del Muro-Casas, Dra.
- Marcelo Gómez Palacio-Gastélum, Dr.
- Nicolás Addiel Serafín-Higuera, Dr.
Published 2024-12-17
Keywords
- Pericoronitis,
- tercer molar impactado,
- Apoptosis,
- BAX,
- Bcl-2
Abstract
Los terceros molares pueden presentar complicaciones, como pericoronitis e impactación, en las cuales participan procesos celulares como proliferación celular y apoptosis, que a su vez se han relacionado con lesiones epiteliales odontogénicas. Estudios sobre la expresión de proteínas que regulan la apoptosis, como BAX y Bcl-2, en folículos dentarios de terceros molares impactados y pericoronitis son escasos. Este estudio analizó clínica y radiográficamente casos de pacientes con terceros molares, y evaluó la expresión de BAX y Bcl-2 en folículos mediante inmunohistoquímica. Se encontró expresión no uniforme de BAX y Bcl-2 en los folículos con una intensidad de la expresión de BAX mayor en presencia de pericoronitis, mientras que la expresión de Bcl-2 fue menor. El análisis de otros marcadores de apoptosis podría ayudar a entender la importancia del proceso en complicaciones en terceros molares.
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References
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Alhaija, E. S. A., & Wazwaz, F. T. (2019). Third molar tooth agenesis and pattern of impaction in patients with palatally displaced canines. The Angle orthodontist, 89(1), 64–70. https://doi.org/10.2319/031318-203.1
Almeida, L. E., Loyd, D., Boettcher, D., Kraft, O., & Zammuto, S. (2024). Immunohistochemical Analysis of Dentigerous Cysts and Odontogenic Keratocysts Associated with Impacted Third Molars-A Systematic Review. Diagnostics (Basel, Switzerland), 14(12), 1246. https://doi.org/10.3390/diagnostics14121246
Anand, S., Kashyap, B., Kumar, G. R., Shruthi, B. S., & Supriya, A. N. (2015). Pericoronal radiolucencies with significant pathology: clinico-histopathologic evaluation. Biomedical journal, 38(2), 148–152. https://doi.org/10.4103/2319-4170.133779
Bardellini, E., Amadori, F., Santoro, A., Conti, G., Orsini, G., & Majorana, A. (2016). Odontoblastic Cell Quantification and Apoptosis within Pulp of Deciduous Teeth Versus Pulp of Permanent Teeth. The Journal of clinical pediatric dentistry, 40(6), 450–455. https://doi.org/10.17796/1053-4628-40.6.450
Candotto V, Oberti L, Gabrione F, Scarano A, Rossi D, Romano M. Complication in third molar extractions. J Biol Regul Homeost Agents. 2019 May-Jun;33(3 Suppl. 1):169-172. DENTAL SUPPLEMENT. Pub Med PMID: 31538464.
Caymaz MG, Buhara O. Association of Oral Hygiene and Periodontal Health with Third Molar Pericoronitis: A Cross-Sectional Study. Biomed Res Int. 2021 Feb 28; 2021:6664434.Pub Med PMID: 33728338; Pub Med Central PMCID: PMC7937453.
da Silva, V. P., Meyer, G. L., Daroit, N. B., Maraschin, B. J., de Oliveira, M. G., Visioli, F., & Rados, P. V. (2020). Pericoronal follicles revealing unsuspected odontogenic cysts and inflammatory lesions: A retrospective microscopy study. Indian journal of dental research: official publication of Indian Society for Dental Research, 31(1), 80–84. https://doi.org/10.4103/ijdr.IJDR_459_18
de Mello Palma, V., Danesi, C. C., Arend, C. F., Venturini, A. B., Blaya, D. S., Neto, M. M., Flores, J. A., & Ferrazzo, K. L. (2018). Study of Pathological Changes in the Dental Follicle of Disease-Free Impacted Third Molars. Journal of maxillofacial and oral surgery, 17(4), 611–615. https://doi.org/10.1007/s12663-018-1131-2
Dongol, A., Sagtani, A., Jaisani, M. R., Singh, A., Shrestha, A., Pradhan, A., Acharya, P., Yadav, A. K., Yadav, R. P., Mahat, A. K., Maharjan, I. K., & Pradhan, L. (2018). Dentigerous Cystic Changes in the Follicles Associated with Radiographically Normal Impacted Mandibular Third Molars. International journal of dentistry, 2018, 2645878. https://doi.org/10.1155/2018/2645878
Edamatsu, M., Kumamoto, H., Ooya, K., & Echigo, S. (2005). Apoptosis-related factors in the epithelial components of dental follicles and dentigerous cysts associated with impacted third molars of the mandible. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 99(1), 17–23. https://doi.org/10.1016/j.tripleo.2004.04.016
Escobar, E., Gómez-Valenzuela, F., Peñafiel, C., Chimenos-Küstner, E., & Pérez-Tomás, R. (2023). Aberrant immunoexpression of p53 tumour-suppressor and Bcl-2 family proteins (Bcl-2 and Bax) in ameloblastomas and odontogenic keratocysts. Journal of clinical and experimental dentistry, 15(2), e125.
Esen, A., Isik, K., Findik, S., & Suren, D. (2016). Histopathological evaluation of dental follicles of clinically symptomatic and asymptomatic impacted third molars. Nigerian journal of clinical practice, 19(5), 616–621. https://doi.org/10.4103/1119-3077.188700
Ghaeminia, H., Nienhuijs, M. E., Toedtling, V., Perry, J., Tummers, M., Hoppenreijs, T. J., Van der Sanden, W. J., & Mettes, T. G. (2020). Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth. The Cochrane database of systematic reviews, 5(5), CD003879. https://doi.org/10.1002/14651858.CD003879.pub5
Gupta, P., Naik, S. R., Ashok, L., Khaitan, T., & Shukla, A. K. (2020). Prevalence of periodontitis and caries on the distal aspect of mandibular second molar adjacent to impacted mandibular third molar: A guide for oral health promotion. Journal of family medicine and primary care, 9(5), 2370–2374. https://doi.org/10.4103/jfmpc.jfmpc_37_20
Haidry, N., Singh, M., Mamatha, N. S., Shivhare, P., Girish, H. C., Ranganatha, N., & Kashyap, S. (2018). Histopathological Evaluation of Dental Follicle Associated with Radiographically Normal Impacted Mandibular Third Molars. Annals of maxillofacial surgery, 8(2), 259–264. https://doi.org/10.4103/ams.ams_215_18
Hounsome, J., Pilkington, G., Mahon, J., Boland, A., Beale, S., Kotas, E., Renton, T., & Dickson, R. (2020). Prophylactic removal of impacted mandibular third molars: a systematic review and economic evaluation. Health technology assessment (Winchester, England), 24(30), 1–116. https://doi.org/10.3310/hta24300
Kang, F., Huang, C., Sah, M. K., & Jiang, B. (2016). Effect of Eruption Status of the Mandibular Third Molar on Distal Caries in the Adjacent Second Molar. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 74(4), 684–692. https://doi.org/10.1016/j.joms.2015.11.024
Katsarou, T., Kapsalas, A., Souliou, C., Stefaniotis, T., & Kalyvas, D. (2019). Pericoronitis: A clinical and epidemiological study in greek military recruits. Journal of clinical and experimental dentistry, 11(2), e133–e137. https://doi.org/10.4317/jced.55383
Korshunova, A. Y., Blagonravov, M. L., Neborak, E. V., Syatkin, S. P., Sklifasovskaya, A. P., Semyatov, S. M., & Agostinelli, E. (2021). BCL2 regulated apoptotic process in myocardial ischemia reperfusion injury (Review). International journal of molecular medicine, 47(1), 23–36. https://doi.org/10.3892/ijmm.2020.4781
Kucukkolbasi, H., Esen, A., & Erinanc, O. H. (2014). Immunohistochemical analysis of Ki-67 in dental follicle of asymptomatic impacted third molars. Journal of oral and maxillofacial pathology: JOMFP, 18(2), 189–193. https://doi.org/10.4103/0973-029X.140737
Kumar, VR, Yadav P, Kahsu E, Girkar F, Chakraborty R. Prevalence and Pattern of Mandibular Third Molar Impaction in Eritrean Population: A Retrospective Study. J Contemp Dent Pract. 2017;18(2):100-106. Published 2017 Feb 1. doi:10.5005/jp-journals-10024-1998
Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014). Reactive oxygen species in inflammation and tissue injury. Antioxidants & redox signaling, 20(7), 1126–1167. https://doi.org/10.1089/ars.2012.5149
NIH, National Institute of Health and Care Excellence. Guidance on the extraction of wisdom teeth. TA1. London: NICE 2000 https://nice.org.uk/guidance/ta1 (acceso 20 enero 2022)
Rahman, F., Bhargava, A., Tippu, S. R., Kalra, M., Bhargava, N., Kaur, I., & Srivastava, S. (2013). Analysis of the immunoexpression of Ki-67 and Bcl-2 in the pericoronal tissues of impacted teeth, dentigerous cysts and gingiva using software image analysis. Dental research journal, 10(1), 31–37. https://doi.org/10.4103/1735-3327.111764
Razavi, S. M., Hasheminia, D., Mehdizade, M., Movahedian, B., & Keshani, F. (2012). The relation of pericoronal third molar follicle dimension and bcl-2/ki-67 expression: An immunohistochemical study. Dental research journal, 9(Suppl 1), S26–S31. https://doi.org/10.4103/1735-3327.107931
Renton, T., & Wilson, N. H. (2016). Problems with erupting wisdom teeth: signs, symptoms, and management. The British journal of general practice: the journal of the Royal College of General Practitioners, 66(649), e606–e608. https://doi.org/10.3399/bjgp16X686509
Ribeiro, MHB, Ribeiro PC, Retamal-Valdes B, Feres M, Canabarro A. Microbial profile of symptomatic pericoronitis lesions: a cross-sectional study. J Appl Oral Sci. 2019 Nov 28;28: e20190266.Pub Med. PMID: 31800877; Pub Med Central PMCID: PMC6886397.
Satheesan, E., Tamgadge, S., Tamgadge, A., Bhalerao, S., & Periera, T. (2016). Histopathological and Radiographic Analysis of Dental Follicle of Impacted Teeth Using Modified Gallego's Stain. Journal of clinical and diagnostic research: JCDR, 10(5), ZC106–ZC111. https://doi.org/10.7860/JCDR/2016/16707.7838
Tenório, J. R., Santana, T., Queiroz, S. I., de Oliveira, D. H., & Queiroz, L. M. (2018). Apoptosis and cell cycle aberrations in epithelial odontogenic lesions: An evidence by the expression of p53, Bcl-2 and Bax. Medicina oral, patología oral y cirugía bucal, 23(2), e120–e125. https://doi.org/10.4317/medoral.22019
Toedtling, V., Forouzanfar, T., & Brand, H. S. (2023). Historical aspects about third molar removal versus retention and distal surface caries in the second mandibular molar adjacent to impacted third molars. British dental journal, 234(4), 268–273. https://doi.org/10.1038/s41415-023-5532-3
Valladares, K. J. P., Balbinot, K. M., Lopes de Moraes, A. T., Kataoka, M. S. D. S., Ramos, A. M. P. C., Ramos, R. T. J., da Silva, A. L. D. C., Mesquita, R. A., Normando, D., Alves Júnior, S. M., & Pinheiro, J. J. V. (2021). HIF-1α Is Associated with Resistance to Hypoxia-Induced Apoptosis in Ameloblastoma. International journal of dentistry, 2021, 3060375. https://doi.org/10.1155/2021/3060375
Vigneswaran, A. T., & Shilpa, S. (2015). The incidence of cysts and tumors associated with impacted third molars. Journal of pharmacy & bioallied sciences, 7(Suppl 1), S251–S254. https://doi.org/10.4103/0975-7406.155940
Villafuerte-Palacios, L. E., German Santa Cruz, L. A. B., Cámara Chávez, R., & Mallma Medina, A. S. (2016). Cambios histopatológicos de los folículos dentales en relación al espacio pericoronario y posición de terceros molares no erupcionados. Revista Estomatológica Herediana, 26(4), 206-214.
Villalba, L., Stolbizer, F., Blasco, F., Mauriño, N. R., Piloni, M. J., & Keszler, A. (2012). Pericoronal follicles of asymptomatic impacted teeth: a radiographic, histomorphologic, and immunohistochemical study. International journal of dentistry, 2012, 935310. https://doi.org/10.1155/2012/935310
Ye, Z. X., Qian, W. H., Wu, Y. B., & Yang, C. (2021). Pathologies associated with the mandibular third molar impaction. Science progress, 104(2), 368504211013247. https://doi.org/10.1177/00368504211013247
Yilmaz, S., Adisen, M. Z., Misirlioglu, M., & Yorubulut, S. (2016). Assessment of Third Molar Impaction Pattern and Associated Clinical Symptoms in a Central Anatolian Turkish Population. Medical principles and practice: international journal of the Kuwait University, Health Science Centre, 25(2), 169–175. https://doi.org/10.1159/000442416
Alalwani A, Buhara O, Tüzüm MŞ. Oral Health-Related Quality of Life and the Use of Oral and Topical Nonsteroidal Anti-Inflammatory Drugs for Pericoronitis. Med Sci Monit. 2019; 25:9200-6. https://doi.org/10.12659/msm.918085
Alhaija, E. S. A., & Wazwaz, F. T. (2019). Third molar tooth agenesis and pattern of impaction in patients with palatally displaced canines. The Angle orthodontist, 89(1), 64–70. https://doi.org/10.2319/031318-203.1
Almeida, L. E., Loyd, D., Boettcher, D., Kraft, O., & Zammuto, S. (2024). Immunohistochemical Analysis of Dentigerous Cysts and Odontogenic Keratocysts Associated with Impacted Third Molars-A Systematic Review. Diagnostics (Basel, Switzerland), 14(12), 1246. https://doi.org/10.3390/diagnostics14121246
Anand, S., Kashyap, B., Kumar, G. R., Shruthi, B. S., & Supriya, A. N. (2015). Pericoronal radiolucencies with significant pathology: clinico-histopathologic evaluation. Biomedical journal, 38(2), 148–152. https://doi.org/10.4103/2319-4170.133779
Bardellini, E., Amadori, F., Santoro, A., Conti, G., Orsini, G., & Majorana, A. (2016). Odontoblastic Cell Quantification and Apoptosis within Pulp of Deciduous Teeth Versus Pulp of Permanent Teeth. The Journal of clinical pediatric dentistry, 40(6), 450–455. https://doi.org/10.17796/1053-4628-40.6.450
Candotto V, Oberti L, Gabrione F, Scarano A, Rossi D, Romano M. Complication in third molar extractions. J Biol Regul Homeost Agents. 2019 May-Jun;33(3 Suppl. 1):169-172. DENTAL SUPPLEMENT. Pub Med PMID: 31538464.
Caymaz MG, Buhara O. Association of Oral Hygiene and Periodontal Health with Third Molar Pericoronitis: A Cross-Sectional Study. Biomed Res Int. 2021 Feb 28; 2021:6664434.Pub Med PMID: 33728338; Pub Med Central PMCID: PMC7937453.
da Silva, V. P., Meyer, G. L., Daroit, N. B., Maraschin, B. J., de Oliveira, M. G., Visioli, F., & Rados, P. V. (2020). Pericoronal follicles revealing unsuspected odontogenic cysts and inflammatory lesions: A retrospective microscopy study. Indian journal of dental research: official publication of Indian Society for Dental Research, 31(1), 80–84. https://doi.org/10.4103/ijdr.IJDR_459_18
de Mello Palma, V., Danesi, C. C., Arend, C. F., Venturini, A. B., Blaya, D. S., Neto, M. M., Flores, J. A., & Ferrazzo, K. L. (2018). Study of Pathological Changes in the Dental Follicle of Disease-Free Impacted Third Molars. Journal of maxillofacial and oral surgery, 17(4), 611–615. https://doi.org/10.1007/s12663-018-1131-2
Dongol, A., Sagtani, A., Jaisani, M. R., Singh, A., Shrestha, A., Pradhan, A., Acharya, P., Yadav, A. K., Yadav, R. P., Mahat, A. K., Maharjan, I. K., & Pradhan, L. (2018). Dentigerous Cystic Changes in the Follicles Associated with Radiographically Normal Impacted Mandibular Third Molars. International journal of dentistry, 2018, 2645878. https://doi.org/10.1155/2018/2645878
Edamatsu, M., Kumamoto, H., Ooya, K., & Echigo, S. (2005). Apoptosis-related factors in the epithelial components of dental follicles and dentigerous cysts associated with impacted third molars of the mandible. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 99(1), 17–23. https://doi.org/10.1016/j.tripleo.2004.04.016
Escobar, E., Gómez-Valenzuela, F., Peñafiel, C., Chimenos-Küstner, E., & Pérez-Tomás, R. (2023). Aberrant immunoexpression of p53 tumour-suppressor and Bcl-2 family proteins (Bcl-2 and Bax) in ameloblastomas and odontogenic keratocysts. Journal of clinical and experimental dentistry, 15(2), e125.
Esen, A., Isik, K., Findik, S., & Suren, D. (2016). Histopathological evaluation of dental follicles of clinically symptomatic and asymptomatic impacted third molars. Nigerian journal of clinical practice, 19(5), 616–621. https://doi.org/10.4103/1119-3077.188700
Ghaeminia, H., Nienhuijs, M. E., Toedtling, V., Perry, J., Tummers, M., Hoppenreijs, T. J., Van der Sanden, W. J., & Mettes, T. G. (2020). Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth. The Cochrane database of systematic reviews, 5(5), CD003879. https://doi.org/10.1002/14651858.CD003879.pub5
Gupta, P., Naik, S. R., Ashok, L., Khaitan, T., & Shukla, A. K. (2020). Prevalence of periodontitis and caries on the distal aspect of mandibular second molar adjacent to impacted mandibular third molar: A guide for oral health promotion. Journal of family medicine and primary care, 9(5), 2370–2374. https://doi.org/10.4103/jfmpc.jfmpc_37_20
Haidry, N., Singh, M., Mamatha, N. S., Shivhare, P., Girish, H. C., Ranganatha, N., & Kashyap, S. (2018). Histopathological Evaluation of Dental Follicle Associated with Radiographically Normal Impacted Mandibular Third Molars. Annals of maxillofacial surgery, 8(2), 259–264. https://doi.org/10.4103/ams.ams_215_18
Hounsome, J., Pilkington, G., Mahon, J., Boland, A., Beale, S., Kotas, E., Renton, T., & Dickson, R. (2020). Prophylactic removal of impacted mandibular third molars: a systematic review and economic evaluation. Health technology assessment (Winchester, England), 24(30), 1–116. https://doi.org/10.3310/hta24300
Kang, F., Huang, C., Sah, M. K., & Jiang, B. (2016). Effect of Eruption Status of the Mandibular Third Molar on Distal Caries in the Adjacent Second Molar. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 74(4), 684–692. https://doi.org/10.1016/j.joms.2015.11.024
Katsarou, T., Kapsalas, A., Souliou, C., Stefaniotis, T., & Kalyvas, D. (2019). Pericoronitis: A clinical and epidemiological study in greek military recruits. Journal of clinical and experimental dentistry, 11(2), e133–e137. https://doi.org/10.4317/jced.55383
Korshunova, A. Y., Blagonravov, M. L., Neborak, E. V., Syatkin, S. P., Sklifasovskaya, A. P., Semyatov, S. M., & Agostinelli, E. (2021). BCL2 regulated apoptotic process in myocardial ischemia reperfusion injury (Review). International journal of molecular medicine, 47(1), 23–36. https://doi.org/10.3892/ijmm.2020.4781
Kucukkolbasi, H., Esen, A., & Erinanc, O. H. (2014). Immunohistochemical analysis of Ki-67 in dental follicle of asymptomatic impacted third molars. Journal of oral and maxillofacial pathology: JOMFP, 18(2), 189–193. https://doi.org/10.4103/0973-029X.140737
Kumar, VR, Yadav P, Kahsu E, Girkar F, Chakraborty R. Prevalence and Pattern of Mandibular Third Molar Impaction in Eritrean Population: A Retrospective Study. J Contemp Dent Pract. 2017;18(2):100-106. Published 2017 Feb 1. doi:10.5005/jp-journals-10024-1998
Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014). Reactive oxygen species in inflammation and tissue injury. Antioxidants & redox signaling, 20(7), 1126–1167. https://doi.org/10.1089/ars.2012.5149
NIH, National Institute of Health and Care Excellence. Guidance on the extraction of wisdom teeth. TA1. London: NICE 2000 https://nice.org.uk/guidance/ta1 (acceso 20 enero 2022)
Rahman, F., Bhargava, A., Tippu, S. R., Kalra, M., Bhargava, N., Kaur, I., & Srivastava, S. (2013). Analysis of the immunoexpression of Ki-67 and Bcl-2 in the pericoronal tissues of impacted teeth, dentigerous cysts and gingiva using software image analysis. Dental research journal, 10(1), 31–37. https://doi.org/10.4103/1735-3327.111764
Razavi, S. M., Hasheminia, D., Mehdizade, M., Movahedian, B., & Keshani, F. (2012). The relation of pericoronal third molar follicle dimension and bcl-2/ki-67 expression: An immunohistochemical study. Dental research journal, 9(Suppl 1), S26–S31. https://doi.org/10.4103/1735-3327.107931
Renton, T., & Wilson, N. H. (2016). Problems with erupting wisdom teeth: signs, symptoms, and management. The British journal of general practice: the journal of the Royal College of General Practitioners, 66(649), e606–e608. https://doi.org/10.3399/bjgp16X686509
Ribeiro, MHB, Ribeiro PC, Retamal-Valdes B, Feres M, Canabarro A. Microbial profile of symptomatic pericoronitis lesions: a cross-sectional study. J Appl Oral Sci. 2019 Nov 28;28: e20190266.Pub Med. PMID: 31800877; Pub Med Central PMCID: PMC6886397.
Satheesan, E., Tamgadge, S., Tamgadge, A., Bhalerao, S., & Periera, T. (2016). Histopathological and Radiographic Analysis of Dental Follicle of Impacted Teeth Using Modified Gallego's Stain. Journal of clinical and diagnostic research: JCDR, 10(5), ZC106–ZC111. https://doi.org/10.7860/JCDR/2016/16707.7838
Tenório, J. R., Santana, T., Queiroz, S. I., de Oliveira, D. H., & Queiroz, L. M. (2018). Apoptosis and cell cycle aberrations in epithelial odontogenic lesions: An evidence by the expression of p53, Bcl-2 and Bax. Medicina oral, patología oral y cirugía bucal, 23(2), e120–e125. https://doi.org/10.4317/medoral.22019
Toedtling, V., Forouzanfar, T., & Brand, H. S. (2023). Historical aspects about third molar removal versus retention and distal surface caries in the second mandibular molar adjacent to impacted third molars. British dental journal, 234(4), 268–273. https://doi.org/10.1038/s41415-023-5532-3
Valladares, K. J. P., Balbinot, K. M., Lopes de Moraes, A. T., Kataoka, M. S. D. S., Ramos, A. M. P. C., Ramos, R. T. J., da Silva, A. L. D. C., Mesquita, R. A., Normando, D., Alves Júnior, S. M., & Pinheiro, J. J. V. (2021). HIF-1α Is Associated with Resistance to Hypoxia-Induced Apoptosis in Ameloblastoma. International journal of dentistry, 2021, 3060375. https://doi.org/10.1155/2021/3060375
Vigneswaran, A. T., & Shilpa, S. (2015). The incidence of cysts and tumors associated with impacted third molars. Journal of pharmacy & bioallied sciences, 7(Suppl 1), S251–S254. https://doi.org/10.4103/0975-7406.155940
Villafuerte-Palacios, L. E., German Santa Cruz, L. A. B., Cámara Chávez, R., & Mallma Medina, A. S. (2016). Cambios histopatológicos de los folículos dentales en relación al espacio pericoronario y posición de terceros molares no erupcionados. Revista Estomatológica Herediana, 26(4), 206-214.
Villalba, L., Stolbizer, F., Blasco, F., Mauriño, N. R., Piloni, M. J., & Keszler, A. (2012). Pericoronal follicles of asymptomatic impacted teeth: a radiographic, histomorphologic, and immunohistochemical study. International journal of dentistry, 2012, 935310. https://doi.org/10.1155/2012/935310
Ye, Z. X., Qian, W. H., Wu, Y. B., & Yang, C. (2021). Pathologies associated with the mandibular third molar impaction. Science progress, 104(2), 368504211013247. https://doi.org/10.1177/00368504211013247
Yilmaz, S., Adisen, M. Z., Misirlioglu, M., & Yorubulut, S. (2016). Assessment of Third Molar Impaction Pattern and Associated Clinical Symptoms in a Central Anatolian Turkish Population. Medical principles and practice: international journal of the Kuwait University, Health Science Centre, 25(2), 169–175. https://doi.org/10.1159/000442416